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Sunday sees the initial Wear-Tyne derby since 2024, but who will emerge victorious – Sunderland or Newcastle?
"For most of last season, you couldn't have imagined the Wearside club rising to the top flight and challenging with Eddie Howe's Newcastle, much less being above them in the table," commented analyst Chris Sutton.
"Things are very different now, and the way they play makes me think they've got a genuine opportunity."
The analyst is providing forecasts for all 380 Premier League games this season, in competition with AI, fans and a assortment of guests.
For week 16, he is challenged by England Gaming star Daniel 'Stingray' Ray.
Ray is going for glory for the England's esports team – the Football Association's formal esports team – at the gaming title Uefa eEuro 2025 finals tournament, which takes place at Twickenham Stadium on Saturday.
You can watch Uefa's YouTube, IG Live and short-form video channels, as well as the official Twitch channel and YouTube and the national team's Twitch.
Are you in alignment with their predictions? Feel free to submit your own predictions below.
The most commonly selected scoreline picked for each game is featured in the scoreboards at the bottom of this page.
Predicting the right outcome (selecting a win, draw or defeat) is worth ten points. An accurate scoreline earns 40 points.
Ray, who competes for his club side and Manchester City as well as England, is competing for the first time at the eEuros finals after getting through the qualification rounds.
A group of eight will play for their countries at the finals in a single-elimination, competing for a substantial cash prize and a coveted spot in the world finals play-offs, with the Danish representative Anders Vejrgang looking to retain the title he won last year.
"My mindset is really good for it," Ray remarked. "There's a really good coach with me and preparation has been going well.
"It is invariably an honour to play for your country. Of course when you are younger, you fantasise about doing it as an actual footballer, but when you enter this profession and there is an chance to represent England, donning the national jersey is something unique.
"I overcame Vejrgang 9-4 in qualifying to get here. I've played against him over the course of the season just in practice, and in other tournaments before - but I'd not previously defeated him in a tournament before.
"I believe he is the number one in the world so beating him in a tournament like this just gives you a massive injection of confidence."
Premier League Weekend Preview
Saturday, 13 December
Chelsea vs Everton
Stamford Bridge, 15:00 GMT
The Blues were outstanding against Arsenal at the end of November, when they secured a point after going down to 10 men, and I was thinking they've turned a corner, they could potentially be title contenders.
Since then, however, they were outfought by Leeds, looked flat against Bournemouth and this week got beaten by Atalanta in the Champions League.
So head coach Enzo Maresca is in need of a win here to get back on track, but it won't be easy because the Merseyside club are such a potent team.
Their key midfielders are playing really well and Everton have got a bit of form at the moment.
Current evidence suggests you would likely back Everton, while the most sensible prediction would probably be a draw, but I'm going against logic.
Chelsea haven't given me any good cause to back them recently, but I just have a hunch Chelsea will emerge victorious because they are at home and they are due a win.
Sutton's prediction: 2-1
Stingray's prediction: With this being at the Bridge, I am going to back Chelsea. I think they will start off really well and go 2-0 up, then Everton will nick one back but then Chelsea score late. 3-1
AI's prediction: 2-0
Liverpool vs Brighton
Anfield, 15:00 GMT
I am at this game and it will be intriguing to see what we get from Liverpool.
I am really pleased for Reds boss Arne Slot to get such a important victory at Inter Milan on Tuesday after all the controversy with Mohamed Salah this week.
Slot shouldn't need to put up with that nonsense. I know Salah has been a icon for the club but essentially Slot just wants to win games and there is no bias in his team selection.
Liverpool changed their shape against Inter and went with a midfield diamond formation and two up top.
All the talk is going to be talking about whether Salah is included for this game, but the only way he is going to be reintegrated is if he apologises.
Slot's attention will be on winning this game, but it is a challenging encounter.
One might suggest it is the same for most teams but I find Brighton so hard to predict. I always feel they have got a goal in them, but they are quite open too.
The Merseysiders need to get back to winning consistently, but I am not sure how much their exertions at the San Siro will have taken out of them.
I've selected a couple of Brighton players in my Fantasy Premier League side, so they will likely do poorly - but I do fancy them to get something at Anfield.
Sutton's prediction: 2-2
Stingray's prediction: This is a game which is going to give Liverpool a bit more of their confidence back. Obviously they had a good win in midweek and they can build more momentum here. 2-1
AI's prediction: 3-1
Sunday, 14 December
Sunderland vs Newcastle
Stadium of Light, 14:00 GMT
The Black Cats have had the benefit of a free week while Newcastle had to work so hard against Bayer Leverkusen on Wednesday, only to let their lead slip away late on.
Aside from their excellent performance against Everton a couple of weeks ago, Newcastle's away form hasn't been great, particularly straight after they've played in the Champions League.
I am expecting that tendency to continue on Sunday, and their lack of freshness is likely to be a significant issue in how this game goes because of their rivals' energetic style.
We saw how incessant Regis le Bris's side are. They overpowered the Gunners, and it was a joy to watch.
Many pundits talks about how Granit Xhaka has been outstanding for the Black Cats, and he has been superb, but Noah Sadiki, who plays alongside him, has also been one of the signings of the season and deserves some attention too.
All signs point to this being the best game|most exciting fixture